ZIA CP010131 04021 (ZIA) | |||
---|---|---|---|
Title | Cancer following radiotherapy for benign gynecologic disorders | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Little, Mark | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $30,751 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Bladder (6.0%) Breast (6.0%) Cervical Cancer (6.0%) Colon/Rectum (13.0%) Hodgkins disease (6.0%) Kidney Cancer (6.0%) Kidney Disease (6.0%) Leukemia (12.0%) Multiple Myeloma (6.0%) Non Hodgkins Lymphoma (7.0%) Ovarian Cancer (7.0%) Pancreas (6.0%) Stomach (7.0%) Uterine (6.0%) |
||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
|||
Abstract | |||
Cancer incidence is being evaluated in a multi-center retrospective cohort study of nearly 13,000 women who had been treated with radiation for benign gynecologic disorders (BGD) between 1925 and 1966. Organ doses were reconstructed for individual women. The most recent analysis was conducted in 2010-2011. Analyses to date have revealed excesses of acute and myelocytic leukemias but no increase in chronic lymphocytic leukemia, lymphomas or multiple myelome. The excess leukemia risk was the same as for women irradiated for cancer of the uterine cervix or corpus, despite substantially lower average radiation doses to bone marrow as for women treated for malignant disease. This most likely is due to the killing of potentially leukemic stem cells in the most highly irradiated parts of the bone marrow. Radiation dose-response relationships also were seen for cancers of the bladder, colon, rectum and ovary but not for cancer of the uterus, which appears to be a radio-resistant organ. Studies of women irradiated for BGD, together with studies of women treated with higher doses of radiation for uterine cancer, provide quantitative information on cancer risks associated with a broad range of pelvic radiation exposure. |